The SELH Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, and Mouse antigen. The SELH Rabbit Polyclonal Antibody has been validated for the following applications: Western Blot.
Description
This gene encodes a nucleolar protein: which belongs to the SelWTH family. It functions as an oxidoreductase: and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways: promote mitochondrial biogenesis and mitochondrial function: and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein: containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon: which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure: designated the Sec insertion sequence (SECIS) element: that is necessary for the recognition of UGA as a Sec codon: rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene